Npgrj_nn_1531 1343..1349
نویسندگان
چکیده
In Alzheimer disease, increased b-secretase (BACE1) activity has been associated with neurodegeneration and accumulation of amyloid precursor protein (APP) products. Thus, inactivation of BACE1 could be important in the treatment of Alzheimer disease. In this study, we found that lowering BACE1 levels using lentiviral vectors expressing siRNAs targeting BACE1 reduced amyloid production and the neurodegenerative and behavioral deficits in APP transgenic mice, a model of Alzheimer disease. Our results suggest that lentiviral vector delivery of BACE1 siRNA can specifically reduce the cleavage of APP and neurodegeneration in vivo and indicate that this approach could have potential therapeutic value for treatment of Alzheimer disease.
منابع مشابه
Regulation of transcription by SMU.1349, a TetR family regulator, in Streptococcus mutans.
The TetR family of transcriptional regulators is ubiquitous in bacteria, where it plays an important role in bacterial gene expression. Streptococcus mutans, a gram-positive pathogen considered to be the primary etiological agent in the formation of dental caries, encodes at least 18 TetR regulators. Here we characterized one such TetR regulator, SMU.1349, encoded by the TnSmu2 operon, which ap...
متن کاملClin Pharmacokinet 2003; 42 (15): 1331-1357
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1331 1. Nuclear Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1332 1.1 Orphan Receptors . . . . . . . . . . . . . . . . . . . . ....
متن کاملERS TASK FORCE Respiratory intermediate care units: a European survey European Respiratory Society Task Force on epidemiology of respiratory intermediate care in Europe
Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1344 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Geographical distribution and type of units . . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Location . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Type of intervention according to different levels of care . . . . . . . . . . . . . . ....
متن کاملRespiratory intermediate care units: a European survey.
Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1344 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Geographical distribution and type of units . . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Location . . . . . . . . . . . . . . . . . . . . . . . . . . 1345 Type of intervention according to different levels of care . . . . . . . . . . . . . . ....
متن کاملCertain inequalities involving the k-Struve function
We aim to introduce a k-Struve function and investigate its various properties, including mainly certain inequalities associated with this function. One of the inequalities given here is pointed out to be related to the so-called classical Turán-type inequality. We also present a differential equation, several recurrence relations, and integral representations for this k-Struve function.
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